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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SYK
All Species:
26.36
Human Site:
Y568
Identified Species:
58
UniProt:
P43405
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.3
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P43405
NP_001128524.1
635
72066
Y568
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
Chimpanzee
Pan troglodytes
XP_520123
544
61880
K486
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
Rhesus Macaque
Macaca mulatta
XP_001100834
635
72070
Y568
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
Dog
Lupus familis
XP_850411
644
73172
Y577
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
Cat
Felis silvestris
Mouse
Mus musculus
P48025
629
71358
Y562
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
Rat
Rattus norvegicus
Q64725
629
71510
Y562
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001026601
613
69811
Y546
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
K
G
Frog
Xenopus laevis
NP_001083616
609
69575
Y542
L
M
W
E
A
Y
S
Y
G
L
K
P
Y
L
R
Zebra Danio
Brachydanio rerio
NP_998008
586
67629
K528
Q
K
P
Y
K
G
M
K
G
N
E
V
I
Q
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24145
939
104255
L863
T
I
W
E
M
F
S
L
G
A
P
P
Y
G
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001180232
837
93621
R758
T
L
W
E
M
N
S
R
G
A
Q
P
Y
G
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.5
99
91.1
N.A.
92.1
91
N.A.
N.A.
77.4
67.7
65.9
N.A.
25.5
N.A.
N.A.
26.5
Protein Similarity:
100
85.6
99.5
94.4
N.A.
94.4
93.6
N.A.
N.A.
87.4
79
77.4
N.A.
39.9
N.A.
N.A.
40.7
P-Site Identity:
100
6.6
100
100
N.A.
100
100
N.A.
N.A.
93.3
73.3
6.6
N.A.
46.6
N.A.
N.A.
40
P-Site Similarity:
100
13.3
100
100
N.A.
100
100
N.A.
N.A.
100
80
20
N.A.
53.3
N.A.
N.A.
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
64
0
0
0
0
19
0
0
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
82
0
0
0
0
0
0
19
0
0
0
19
% E
% Phe:
0
0
0
0
0
64
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
19
0
0
100
0
0
0
0
19
55
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
10
0
0
0
0
0
0
0
0
0
0
10
0
0
% I
% Lys:
0
19
0
0
10
0
0
19
0
0
64
0
0
10
0
% K
% Leu:
64
10
0
0
0
0
0
10
0
10
0
0
0
10
0
% L
% Met:
0
64
0
0
19
0
19
0
0
0
0
0
0
0
19
% M
% Asn:
0
0
0
0
0
10
0
0
0
10
0
0
0
0
0
% N
% Pro:
0
0
19
0
0
0
0
0
0
0
10
82
0
0
0
% P
% Gln:
19
0
0
0
0
0
0
0
0
55
10
0
0
10
0
% Q
% Arg:
0
0
0
0
10
0
0
10
0
0
0
0
0
46
10
% R
% Ser:
0
0
0
0
0
0
82
0
0
10
0
0
0
0
0
% S
% Thr:
19
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
19
0
0
0
% V
% Trp:
0
0
82
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
19
0
10
0
64
0
0
0
0
82
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _